The operative, Abdurakhmon Uzbeki (abdoo-rakman ooz-beki), is alleged to have been a "close associate" of IS leader Abu Bakr al-Baghdadi (ah-boo oh-mar ahl bahg-dahd-ee).
Central Command spokesman, Col. John Thomas, said Uzbeki was killed in a ground operation April 6 near Mayadan, in eastern Syria.
Thomas said Uzbeki helped IS move foreign fighters and funds, and played a key role in plotting terror attacks. Thomas didn't provide details on Uzbeki's role in the Istanbul attack, in which a gunman opened fire inside a crowded nightclub. Dozens of people were wounded.
Thomas was speaking via teleconference to Pentagon reporters Friday.
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